Product Identification
【Product Name】Ethyl 4-chloro-3-oxobutanoate
【Synonyms】4-氯乙酰乙酸乙酯
【CAS】638-07-3
【Formula】C6H9ClO3
【Molecular Weight】164.59
【EINECS】211-317-0
【RTECS】AK5110000
【RTECS Class】Other
【Beilstein/Gmelin】1761275
【Beilstein Reference】4-03-00-01550
【EC Class】toxic, corrosive, sensitizing, dangerous for the environment

Physical and Chemical Properties
【Appearance】Clear colorless to pale yellow red liquid. Acetic odor.
【Solubility in water】Slightly soluble
【Melting Point】-8
【Boiling Point】236
【Vapor Pressure】0.05 (25 C)
【Density】1.21 g/cm3
【pKa/pKb】9.56 (pKa)
【Partition Coefficient】1.67
【Heat Of Vaporization】47.2 kJ/mol
【Vapor Density】5.68
【Refractive Index】1.4221 (19 C)

First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Handling and Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Wash clothing before reuse.

Hazards Identification
【Inhalation】Causes respiratory tract irritation. Can produce delayed pulmonary edema.
【Skin】Causes skin irritation.
【Eyes】Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Lachrymator. May cause chemical conjunctivitis.
【Ingestion】Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
【Hazards】When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
【EC Risk Phrase】R 24/25 36/37/38
【EC Safety Phrase】S 26 36/37/39 45
【UN (DOT)】2810

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】Effects may be delayed.

Fire Fighting Measures
【Flash Point】97
【Autoignition】320
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. Extinguishing media: Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
【Fire Potential】Combustible material: may burn but does not ignite ily.

Accidental Release Measures
【Small spills/leaks】Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.

Stability and Reactivity
【Disposal Code】2
【Stability】Stable at room temperature in closed containers under normal storage and handling conditions.
【Incompatibilities】Strong acids, strong bases, strong oxidizing agents.
【Decomposition】Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.

Transport Information
【UN Number】2810
【Hazard Class】6.1
【Packing Group】I; II; III
【HS Code】2918 30 00