Product Identification
【Product Name】2-Chloro-5-nitro-benzamine 2-氯-5-硝基苯胺
【Synonyms】
2-Chloro-5-nitrobenzenamine
5-Nitro-2-chloroaniline
【CAS】6283-25-6
【Formula】C6H5ClN2O2
【Molecular Weight】172.58
【EINECS】228-498-7
【RTECS】BX1500000
【RTECS Class】Other
【Beilstein/Gmelin】2208878
【Beilstein Reference】3-12-00-01661
Physical and Chemical Properties
【Appearance】Dark yellow powder.
【Solubility in water】Insoluble
【Melting Point】119
【pKa/pKb】0.60 (pKb)
【Partition Coefficient】2.23
First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Hazards Identification
【Inhalation】May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
【Skin】May cause skin irritation. The toxicological properties of this material have not been fully investigated.
【Eyes】May cause eye irritation. The toxicological properties of this material have not been fully investigated.
【Ingestion】May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May form methemoglobin which in sufficient concentration causes cyanosis.
【Hazards】When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
【EC Risk Phrase】R 26/27/28 33 51/53
【EC Safety Phrase】S 28 36/37 45 61
【UN (DOT)】2237
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】Acute poisoning may cause rapid heart rate and rapid breathing. Severe headache, CNS disturbances, and tremor may occur. A high incidence of gynecological disorders and excess frequency of spontaneous abortions have been noted. The fetal liver can n-oxygenate aniline to form phenylhydroxylamine. Fetal effects include higher levels of methemoglobin those found in than the mother. Fetal poisoning may occur.
No data were available to assess the potential effects of exposure to aniline during lactation.
No information about possible male reproductive effects was found in available references at the time of this review
【Exposure limit(s)】2 ppm TWA ACGIH
Fire Fighting Measures
【Flash Point】200
【Autoignition】320
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
【Fire Potential】Combustible material: may burn but does not ignite ily.
Accidental Release Measures
【Small spills/leaks】Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Stability and Reactivity
【Incompatibilities】Oxidizing agents.
【Stability】Stable under normal temperatures and pressures.
【Decomposition】Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.
Transport Information
【UN Number】2237
【Hazard Class】6.1
【Packing Group】III