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12δ֪׷
ǰ׻ٿƣ߷Ʒ

ǰ׻ण߰ȫ˵

ǰ׻रȫ˵
Product Identification
Product Name2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
SynonymsAzolmetazin
CAS57-68-1
FormulaC12H14N4O2S
Molecular Weight278.33
EINECS200-346-4
RTECSWO9275000
RTECS ClassTumorigen; Drug; Reproductive Effector
Merck12,9083
Beilstein/Gmelin261304
Beilstein Reference5-25-10-00250

Physical and Chemical Properties
AppearanceOdorless sticky, white or creamy-white crystalline powder. Slightly bitter taste. An antibacterial.
Solubility in water1.5 g/L (30)
Melting Point178 - 179
Boiling Point526
Vapor Pressure4E-11 (25)
Density1.466 g/cm3
pKa/pKb7.45 (pKa)
Partition Coefficient.8
Heat Of Vaporization80.1 kJ/mol
UsageMedication (vet).

First Aid Measures
IngestionNever give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
InhalationRemove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
SkinGet medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
EyesFlush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage
StorageStore in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
HandlingWash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.

Hazards Identification
InhalationMay cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
SkinMay cause skin irritation.
EyesMay cause eye irritation.
IngestionMay cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Exposure Controls/Personal Protection
Personal ProtectionEyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
RespiratorsFollow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Exposure Effectsheadache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.

Fire Fighting Measures
Flash Point272
Fire FightingWear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Fire PotentialThis material is probably combustible.

Accidental Release Measures
Small spills/leaksVacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity
IncompatibilitiesOxidizing agents.
StabilityStable under normal temperatures and pressures.
DecompositionNitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

ữƷᡢĶ廯李лһȻ李5-ĵ1,3-6,8-